The inflammatory sequelae of aortic balloon occlusion in hemorrhagic shock

摘要: Abstract Background Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a hemorrhage control and resuscitative adjunct that has been demonstrated to improve central perfusion during hemorrhagic shock. The aim this study was characterize systemic inflammatory response associated cardiopulmonary sequelae with 30, 60, 90 min shock on release interleukin 6 (IL-6) tumor necrosis factor alpha. Materials methods Anesthetized female Yorkshire swine ( Sus scrofa, weight 70–90 kg) underwent 35% blood volume–controlled followed by thoracic aortic 30 (30-REBOA, n  = 6), 60 (60-REBOA,  = 8), 90 min (90-REBOA,  = 6). This resuscitation whole crystalloid over 6 h. Animals then 48 h critical care sedation, fluid, vasopressor support. Results All animals were successfully induced into without mortality. groups responded rise in pressure above baseline values. IL-6, as measured (picogram per milliliter) at 8 h, significantly elevated from values 60-REBOA 90-REBOA groups: 289 ± 258 versus 10 ± 5; P  = 0.018 630 ± 348;  = 0.007, respectively. There trend toward greater use  = 0.183) increased incidence acute respiratory distress syndrome  = 0.052) across groups. Conclusions REBOA useful supporting shock; however, increasing time results IL-6 release. Clinicians must anticipate inflammation-mediated organ failure post-REBOA patients.