Cell type-specific deficiency of c-kit gene expression in mutant mice of mi/mi genotype.

摘要: The mi locus of mice encodes a novel member the basic-helix-loop-helix-leucine zipper protein family transcription factors (hereafter called factor). In addition to microphthalmus, osteopetrosis, and lack melanocytes, mi/mi genotype are deficient in mast cells. Since c-kit receptor tyrosine kinase plays an important role development cells, since expression by cultured cells from is both mRNA levels, cell deficiency has been attributed at least part c-kit. However, it remained be examined whether was also tissues mice. present study, we skin using situ hybridization immunohistochemistry. Moreover, various other than We found that but not erythroid precursors, testicular germ neurons This suggested regulation factor dependent on types. Mice appeared useful model analyze function whole-animal level.