Management of osteoporosis.

作者: E Michael Lewiecki

DOI: 10.1186/1476-7961-2-9

关键词:

摘要: Osteoporosis or osteopenia occurs in about 44 million Americans, resulting 1.5 fragility fractures per year. The consequences of these include pain, disability, depression, loss independence, and increased mortality. burden to the healthcare system, terms cost resources, is tremendous, with an estimated direct annual USA expenditure $17 billion. With longer life expectancy aging baby-boomer generation, number men women osteoporosis low bone density expected rise over 61 by 2020. a silent disease that causes no symptoms until fracture occurs. Any greatly increases risk future fractures. Most patients are not being diagnosed treated. Even those previous fractures, who at extremely high often It preferable diagnose testing individuals before first If identified, evaluation for contributing factors should be considered. Patients on long-term glucocorticoid therapy especially developing osteoporosis, may sustain lower than taking glucocorticoids. All counseled importance regular weight-bearing exercise adequate daily intake calcium vitamin D. Exposure medications cause drowsiness hypotension minimized. Non-pharmacologic reduce non-skeletal These fall prevention through balance training muscle strengthening, removal hazards home, wearing hip protectors if falling remains high. Pharmacologic can stabilize increase most patients, 50%. By selecting it possible this occurs, initiate appropriate treatment

参考文章(48)
Adele Boskey boskeya@ hss. edu, Bone mineral crystal size. Osteoporosis International. ,vol. 14, pp. 16- 21 ,(2003) , 10.1007/S00198-003-1468-2
NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, Osteoporosis Prevention, Diagnosis, and Therapy JAMA: The Journal of the American Medical Association. ,vol. 285, pp. 785- 795 ,(2001) , 10.1001/JAMA.285.6.785
Writing Group for the Women's Health Initiative Investigators, Writing Group for the Women's Health Initiative Investigators, None, Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial JAMA. ,vol. 288, pp. 321- 333 ,(2002) , 10.1001/JAMA.288.3.321
K.L Bell, N Loveridge, J Power, N Garrahan, B.F Meggitt, J Reeve, Regional differences in cortical porosity in the fractured femoral neck Bone. ,vol. 24, pp. 57- 64 ,(1999) , 10.1016/S8756-3282(98)00143-4
M Luengo, C Picado, L Del Rio, N Guanabens, J M Montserrat, J Setoain, Vertebral fractures in steroid dependent asthma and involutional osteoporosis: a comparative study. Thorax. ,vol. 46, pp. 803- 806 ,(1991) , 10.1136/THX.46.11.803
L. Joseph Melton, Elizabeth J. Atkinson, Michael K. O'Connor, W. Michael O'Fallon, B. Lawrence Riggs, Bone density and fracture risk in men. Journal of Bone and Mineral Research. ,vol. 13, pp. 1915- 1923 ,(1998) , 10.1359/JBMR.1998.13.12.1915
Nancy Fox Ray, Julien K. Chan, Mae Thamer, L. Joseph Melton, Medical Expenditures for the Treatment of Osteoporotic Fractures in the United States in 1995: Report from the National Osteoporosis Foundation Journal of Bone and Mineral Research. ,vol. 12, pp. 24- 35 ,(1997) , 10.1359/JBMR.1997.12.1.24