Infection-Associated Thymic Atrophy
作者： Xi Sun , Lingxin Xu , Mingli Luo , Zhengyu Qian
DOI: 10.3389/FIMMU.2021.652538
关键词:
摘要: The thymus is a vital organ of the immune system that plays an essential role in thymocyte development and maturation. Thymic atrophy occurs with age (physiological thymic atrophy) or as result viral, bacterial, parasitic fungal infection (pathological atrophy). directly results loss thymocytes and/or destruction architecture, indirectly leads to decrease naive T cells limited cell receptor diversity. Thus, it important recognize causes mechanisms induce atrophy. In this review, we highlight current progress infection-associated pathogenic discuss its possible mechanisms. addition, whether extracellular vesicles/exosomes could be potential carriers substances thymus, drugs for treatment Having acknowledged most research serological aspects, look forward possibility extending future work regarding impact neural modulation on
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