Metabolomics in diabetes

作者: Ai-hua Zhang , Shi Qiu , Hong-ying Xu , Hui Sun , Xi-jun Wang

DOI: 10.1016/J.CCA.2013.11.037

关键词:

摘要: Characterization of metabolic changes is key to early detection, treatment, and understanding molecular mechanisms diabetes. Diabetes represents one the most important global health problems. Approximately 90% diabetics have type 2 Identification effective screening markers critical for treatment intervention that can delay and/or prevent complications associated with this chronic disease. Fortunately, metabolomics has introduced new insights into pathology diabetes as well predict disease onset revealed biomarkers improve diagnostics in a range diseases. Small-molecule metabolites an role biological systems represent attractive candidates understand T2D phenotypes. Characteristic patterns be broaden our disorder. This technique-driven review aims demystify T2D, provide updates on applications addressing focus based biomarker discovery.

参考文章(51)
Xiuying Zhang, Yulan Wang, Fuhua Hao, Xianghai Zhou, Xueyao Han, Huiru Tang, Linong Ji, Human serum metabonomic analysis reveals progression axes for glucose intolerance and insulin resistance statuses Journal of Proteome Research. ,vol. 8, pp. 5188- 5195 ,(2009) , 10.1021/PR900524Z
R. M. Salek, M. L. Maguire, E. Bentley, D. V. Rubtsov, T. Hough, M. Cheeseman, D. Nunez, B. C. Sweatman, J. N. Haselden, R. D. Cox, S. C. Connor, J. L. Griffin, A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human Physiological Genomics. ,vol. 29, pp. 99- 108 ,(2007) , 10.1152/PHYSIOLGENOMICS.00194.2006
Yuqian Bao, Tie Zhao, Xiaoyan Wang, Yunping Qiu, Mingming Su, Weiping Jia, Wei Jia, Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers. Journal of Proteome Research. ,vol. 8, pp. 1623- 1630 ,(2009) , 10.1021/PR800643W
Elaine Holmes, Ruey Leng Loo, Jeremiah Stamler, Magda Bictash, Ivan K. S. Yap, Queenie Chan, Tim Ebbels, Maria De Iorio, Ian J. Brown, Kirill A. Veselkov, Martha L. Daviglus, Hugo Kesteloot, Hirotsugu Ueshima, Liancheng Zhao, Jeremy K. Nicholson, Paul Elliott, Human metabolic phenotype diversity and its association with diet and blood pressure Nature. ,vol. 453, pp. 396- 400 ,(2008) , 10.1038/NATURE06882
Thomas J Wang, Martin G Larson, Ramachandran S Vasan, Susan Cheng, Eugene P Rhee, Elizabeth McCabe, Gregory D Lewis, Caroline S Fox, Paul F Jacques, Céline Fernandez, Christopher J O'Donnell, Stephen A Carr, Vamsi K Mootha, Jose C Florez, Amanda Souza, Olle Melander, Clary B Clish, Robert E Gerszten, Metabolite profiles and the risk of developing diabetes Nature Medicine. ,vol. 17, pp. 448- 453 ,(2011) , 10.1038/NM.2307
Anders H. Rosengren, Ramunas Jokubka, Damon Tojjar, Charlotte Granhall, Ola Hansson, Dai-Qing Li, Vini Nagaraj, Thomas M. Reinbothe, Jonatan Tuncel, Lena Eliasson, Leif Groop, Patrik Rorsman, Albert Salehi, Valeriya Lyssenko, Holger Luthman, Erik Renström, Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes Science. ,vol. 327, pp. 217- 220 ,(2010) , 10.1126/SCIENCE.1176827
Tao Zhang, Xiaoyan Wu, Mingzhu Yin, Lijun Fan, Haiyu Zhang, Falin Zhao, Wang Zhang, Chaofu Ke, Guangming Zhang, Yan Hou, Xiaohua Zhou, Ge Lou, Kang Li, None, Discrimination between malignant and benign ovarian tumors by plasma metabolomic profiling using ultra performance liquid chromatography/mass spectrometry Clinica Chimica Acta. ,vol. 413, pp. 861- 868 ,(2012) , 10.1016/J.CCA.2012.01.026
Oliver Fiehn, W. Timothy Garvey, John W. Newman, Kerry H. Lok, Charles L. Hoppel, Sean H. Adams, Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women PLOS ONE. ,vol. 5, pp. 1- 10 ,(2010) , 10.1371/JOURNAL.PONE.0015234
Chao Zhu, Qiong-lin Liang, Ping Hu, Yi-ming Wang, Guo-an Luo, Phospholipidomic identification of potential plasma biomarkers associated with type 2 diabetes mellitus and diabetic nephropathy Talanta. ,vol. 85, pp. 1711- 1720 ,(2011) , 10.1016/J.TALANTA.2011.05.036
Xiang Li, Zhiliang Xu, Xin Lu, Xuehui Yang, Peiyuan Yin, Hongwei Kong, Ying Yu, Guowang Xu, Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry for metabonomics: Biomarker discovery for diabetes mellitus. Analytica Chimica Acta. ,vol. 633, pp. 257- 262 ,(2009) , 10.1016/J.ACA.2008.11.058