Enalapril Attenuates the Exaggerated Sympathetic Response to Physical Stress in Prenatally Programmed Hypertensive Rats
作者： Masaki Mizuno , German Lozano , Khurrum Siddique , Michel Baum , Scott A. Smith
DOI: 10.1161/HYPERTENSIONAHA.113.02330
关键词:
摘要: Adulthood hypertension can be prenatally programmed by maternal dietary protein deprivation. We have shown that the sympathetically mediated pressor response to physical stress is exaggerated in hypertensive (PPH) rats. The mechanisms underlying this abnormal responsiveness remain undetermined. renin–angiotensin system known affect sympathetic nerve activity. Therefore, purpose of study was determine whether inhibition attenuates enhanced and responses PPH Changes renal activity blood pressure hindlimb contraction, stretch, intra-arterial capsaicin administration were assessed control rats treated (from age 3 weeks) with either vehicle or angiotensin-converting enzyme inhibitor enalapril. Conscious resting systolic arterial significantly greater (142±5 mm Hg) than (128±2 after treatment ( P
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sci-hub.se 参考文章(50)
Norma B Ojeda, W Russell Johnson, Terry M Dwyer, Barbara T Alexander, EARLY RENAL DENERVATION PREVENTS DEVELOPMENT OF HYPERTENSION IN GROWTH-RESTRICTED OFFSPRING Clinical and Experimental Pharmacology and Physiology. ,vol. 34, pp. 1212- 1216 ,(2007) , 10.1111/J.1440-1681.2007.04754.X
T. Matsukawa, E. Gotoh, K. Minamisawa, M. Kihara, S. Ueda, H. Shionoiri, M. Ishii, Effects of intravenous infusions of angiotensin II on muscle sympathetic nerve activity in humans American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 261, ,(1991) , 10.1152/AJPREGU.1991.261.3.R690
Scott A. Smith, Maurice A. Williams, Anna K. Leal, Jere H. Mitchell, Mary G. Garry, Exercise pressor reflex function is altered in spontaneously hypertensive rats The Journal of Physiology. ,vol. 577, pp. 1009- 1020 ,(2006) , 10.1113/JPHYSIOL.2006.121558
G.M. Toney, S.W. Mifflin, Time-dependent inhibition of hindlimb somatic afferent transmission within nucleus tractus solitarius: an in vivo intracellular recording study. Neuroscience. ,vol. 68, pp. 445- 453 ,(1995) , 10.1016/0306-4522(95)00156-D
Michelle M. Kett, Kate M. Denton, Renal programming: cause for concern? American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 300, pp. 1- 38 ,(2011) , 10.1152/AJPREGU.00791.2010
G. JANCSÓ, ELISABETH KIRALY, AURELIA JANCSÓ-GÁBOR, Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones Nature. ,vol. 270, pp. 741- 743 ,(1977) , 10.1038/270741A0
Eiki Takimoto, Hunter C Champion, Manxiang Li, Diego Belardi, Shuxun Ren, E Rene Rodriguez, Djahida Bedja, Kathleen L Gabrielson, Yibin Wang, David A Kass, Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy Nature Medicine. ,vol. 11, pp. 214- 222 ,(2005) , 10.1038/NM1175
Eike Hoberg, Gerhard Schuler, Bernd Kunze, Anne-Liese Obermoser, Klaus Hauer, Hans-Peter Mautner, Günter Schlierf, Wolfgang Kübler, Silent myocardial ischemia as a potential link between lack of premonitoring symptoms and increased risk of cardiac arrest during physical stress. American Journal of Cardiology. ,vol. 65, pp. 583- 589 ,(1990) , 10.1016/0002-9149(90)91034-4
Amit Dagan, Jyothsna Gattineni, Vodi Cook, Michel Baum, Prenatal programming of rat proximal tubule Na+/H+ exchanger by dexamethasone American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 292, ,(2007) , 10.1152/AJPREGU.00669.2006
Simon C. Langley-Evans, Alan A. Jackson, Captopril normalises systolic blood pressure in rats with hypertension induced by fetal exposure to maternal low protein diets. Comparative Biochemistry and Physiology Part A: Physiology. ,vol. 110, pp. 223- 228 ,(1995) , 10.1016/0300-9629(94)00177-U