Molecular genetic identification of isolates of the hepatitis A virus (HAV) from monkeys at Adler Primate Center.
作者： Dmitriy I. Dogadov , Lydia I. Korzaya , Anastasia A. Karlsen , Karen K. Kyuregyan
DOI: 10.1111/JMP.12333
关键词:
摘要: BACKGROUND The aim of this study was to assess prevalence and genetic variability hepatitis A virus (HAV) isolates in monkeys born kept at Adler Primate Center, as well imported animals. METHODS fecal samples from various species (n = 119) were studied using reverse transcription seminested PCR, sequencing, phylogenetic analysis. RESULTS HAV RNA detected 2 Macaca mulatta 1 fascicularis (3.8%) Center (n = 79) 11 (27.5%) Chlorocebus pygerythrus (n = 40) Tanzania. Phylogenetic analysis demonstrated that all strains belonged simian genotype V, but differed the prototype V strain (AGM-27) by 5.4%-5.5%. Sequences isolated only 0.1%, suggesting a common source infection. CONCLUSIONS This asymptomatic circulation among it indicated significant diversity within genotype.
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