Carbon monoxide in sepsis.

摘要: Despite modern practices in critical care medicine, sepsis or systemic inflammatory response syndrome remains a leading cause of morbidity and mortality the intensive unit. Thus, need to identify new therapeutic tools for treatment is urgent. In this context, carbon monoxide has become promising molecule that can potentially prevent uncontrolled inflammation sepsis. humans, arises endogenously from degradation heme by oxygenase enzymes. Both synthesized exogenously applied exert antiinflammatory antiapoptotic effects cells tissues. Based on these properties, monoxide, when at low concentration, conferred protection variety cellular rodent models sepsis, furthermore reduced vivo. Therefore, application may have major impact future treatment. This review summarizes evidence salutary various organs, including lung, heart, kidney, liver, intestine, discusses potential translation data into human clinical trials.