DNA Alkylation in Mice with Genetically Different Susceptibility to 1,2-Dimethylhydrazine-induced Colon Carcinogenesis

摘要: Abstract The formation and persistence of methylated purines was determined in mice that received a single s.c. injection 1,2-[ 14 C]dimethylhydrazine (15 mg/kg) were allowed to survive for 12 or 60 hr. In with low susceptibility dimethylhydrazine-induced colon carcinogenesis (C57BL/Ha), concentrations 7-methylguanine O 6 -methylguanine DNA colon, ileum, kidney 40 60% less than high incidence colonic tumors (ICR/Ha). hepatic the extent methylation higher C57BL/Ha ICR/Ha mice. rate loss from similar both strains. all organs investigated metabolic incorporation C into normal bases lower It is concluded carcinogenic response due smaller initial alkylation DNA, which probably reflects differences enzymic metabolism parent carcinogen.