A critical review finds styrene lacks direct endocrine disruptor activity.

摘要: The European Commission lists styrene (S) as an endocrine disruptor based primarily on reports of increased prolactin (PRL) levels in S-exposed workers. US Environmental Protection Agency included S its list chemicals to be tested for activity. Therefore, the database potential activity is assessed. In vitro and vivo screening studies, well non-guideline guideline investigations experimental animals indicate that not associated with (anti)estrogenic, (anti)androgenic, or thyroid-modulating may relevant environment. Studies exposed workers have suggested elevated PRL been further examined a series human animal investigations. While there only one definitively known physiological function PRL, namely stimulation milk production, many normal stress situations lead elevations without any chemical exposure. Animal studies various aspects dopamine (DA), PRL-regulating neurotransmitter, central nervous system did give mechanistic explanations how affect levels. Overall, neuroendocrine disruption regulation cannot deduced from large database. effects could consistently reproduced findings humans represented acute reversible clearly below clinical pathological unspecific workplace-related proposed alternative mode action