Histamine-induced itch and alloknesis (itchy skin) in atopic eczema patients and controls

摘要: Alloknesis ("itchy skin") after histamine iontophoresis was studied together with itch sensations and skin reactions in 19 atopic eczema patients 20 controls at the forearm scapular area. Compared to controls, showed significantly reduced alloknesis or total lack of it area around a site which had been iontophoretically applied, although elicited itching most patients. As previously demonstrated, also developed smaller flares. However, covariance analysis revealed that areas were not statistically related Our results suggest diminished responsiveness primary afferent nerves is compensated by higher central nervous sensitivity reflected more vivid responses histamine. Therefore, we conclude probably key factor spontaneous experienced eczema.