What treatments for rheumatoid arthritis can best be assessed by large, simple, long-term trials?

摘要: If the really important questions in long-term management of rheumatoid arthritis are to be answered reliably, then clinical trials may have undertaken that very much larger and simpler than has previously been case. For sufficient numbers busy clinicians collaborate wholeheartedly with such trials, extra work per patient should slight. In addition, collaborators more recompensed for even slight trouble by pro-rata secretarial and/or locum assistance, so it will actually less them a trial not do so. Two particular discussed illustrate these general principles.