High-Mobility Group Box 1: Missing Link Between Thrombosis and Inflammation?

摘要: High-mobility group box 1 protein (HMGB1) is an abundant nuclear with a dual function. Inside the cell, HMGB1 binds to DNA and modulates variety of intranuclear processes, including transcription. Outside acts as signal tissue damage can promote inflammation, immune responses, regeneration. During sepsis and/or disseminated intravascular coagulation, however, massive accumulation in systemic circulation cause multiple organ failure subsequent lethal outcome. recognized mediator promising therapeutic target for sepsis. Thrombomodulin (TM), natural anticoagulant glycoprotein expressed on surface endothelial cells, plays important role sequestering HMGB1. TM may prevent from reaching remote organs, thereby restricting range action site injury. In this chapter, we review recent progress made defining physiological pathological roles strategies aimed at blocking