Bioelectric Correlates of Kanamycin Intoxication

摘要: Young guinea pigs were given a series of subcutaneous injections kanamycin (400 mg/kg body weight for 8-14 days) and after at least two-week waiting period various electrical responses from the cochlea measured. After experiments was perfused with osmic acid, surface preparations used to obtain sensory (hair) cell counts, cochleograms prepared. In this report relationship between in dices cochlear function (cochlear microphonic: CM. summating potential: SP, whole nerve action AP) degree configuration damage is discussed. The electrode potentials obtained differential technique localized CM SP collected first often third turns. Both (DIF) average (AVE) components studied. results reveral that production inner hair cells alone about 30-40 dB below outer cells...