Efficacy of Exogenous Oral Zinc in Treatment of Patients with Carbonic Anhydrase VI Deficiency

摘要: Abstract Background: We previously described a disorder in 18 patients with decreased parotid saliva gustin/carbonic anhydrase (CA) VI secretion associated loss of taste (hypogeusia) and smell (hyposmia) distorted (dysgeusia) (dysosmia). Because gustin/CAVI is zinc-dependent enzyme we instituted study treatment exogenous zinc to attempt stimulate synthesis/secretion thereby correct the symptoms this disorder. Methods: Fourteen completed study. They were treated 100 mg daily for 4 6 months, an open clinical trial. Both before after treatment, measurements obtained gustin/CAVI, saliva, serum urine zinc, function, and, some patients, examination circumvallate buds by electron microscopy. Results: Treatment success was predicated upon significant increases gustin/CAVI. This occurred 10 14 who labeled responders; they also exhibited improvement acuity, diminution dysgeusia dysosmia increased concentrations serum, urine. Taste bud morphology returned normal each responder whom it measured. No increase nonresponders; no or acuity zinc. However, levels similar those measured responders. Two nonresponders reported dysosmia. did not change from abnormal state 1 nonresponder Conclusions: Zinc effective trace metal ineffective does not. Increased probably stimulation gene responsible Among nonresponders, several possible reasons, including resistance sialylation which may render functionally ineffective. Results suggest hypothesis that trophic factor promotes growth development through its action on stem cells.