Deacylation of Cephalosporins by Lipase Catalysis and Microwave Assisted Transformation on a Solid Support
作者： M. Kidwai , B. Dave , K.R. Bhushan , P. Misra , R.K. Saxena
DOI: 10.1080/10242420290006710
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摘要: Deacylation of cephalosporins has been investigated using enzymatic and microwave activated solid phase techniques. The lipase calatysed deacylation was achieved under cooling with good yields but the method much faster better yields. All synthesised compounds were screened for their antibacterial activity showed results.
informahealthcare.com参考文章(11)
Rajender S. Varma, Manju Varma, Arnab K. Chatterjee, Microwave-assisted deacetylation on alumina: a simple deprotection method Journal of the Chemical Society, Perkin Transactions 1. pp. 999- 1000 ,(1993) , 10.1039/P19930000999
O. H. Jústiz, R. Fernández-Lafuente, J. M. Guisán, P. Negri, G. Pagani, M. Pregnolato, M. Terreni, One-Pot Chemoenzymatic Synthesis of 3‘-Functionalized Cephalosporines (Cefazolin) by Three Consecutive Biotransformations in Fully Aqueous Medium Journal of Organic Chemistry. ,vol. 62, pp. 9099- 9106 ,(1997) , 10.1021/JO971166U
Alexander M. Klibanov, Asymmetric transformations catalyzed by enzymes in organic solvents Accounts of Chemical Research. ,vol. 23, pp. 114- 120 ,(1990) , 10.1021/AR00172A004
Sandrine Deshayes, Marion Liagre, André Loupy, Jean-Louis Luche, Alain Petit, Microwave activation in phase transfer catalysis Tetrahedron. ,vol. 55, pp. 10851- 10870 ,(1999) , 10.1016/S0040-4020(99)00601-8
Richard Gedye, Frank Smith, Kenneth Westaway, Humera Ali, Lorraine Baldisera, Lena Laberge, John Rousell, The use of microwave ovens for rapid organic synthesis Tetrahedron Letters. ,vol. 27, pp. 279- 282 ,(1986) , 10.1016/S0040-4039(00)83996-9
M. Kidwai, K.R. Bhushan, P. Sapra, R.K. Saxena, R. Gupta, Alumina-supported synthesis of antibacterial quinolines using microwaves. Bioorganic & Medicinal Chemistry. ,vol. 8, pp. 69- 72 ,(2000) , 10.1016/S0968-0896(99)00256-4
M. Kidwai, R. Venkataramanan, S. Kohli, Alumina Supported Synthesis of β-Lactams Using Microwave. ChemInform. ,vol. 31, ,(2000) , 10.1002/CHIN.200027104
Enzo Santaniello, Patrizia Ferraboschi, Paride Grisenti, Ada Manzocchi, The biocatalytic approach to the preparation of enantiomerically pure chiral building blocks Chemical Reviews. ,vol. 92, pp. 1071- 1140 ,(1992) , 10.1021/CR00013A016
Rajender S. Varma, Rajender Dahiya, An Expeditious and Solvent-Free Synthesis of 2-Amino-Substituted Isoflav-3-enes Using Microwave Irradiation† Journal of Organic Chemistry. ,vol. 63, pp. 8038- 8041 ,(1998) , 10.1021/JO980985R
George S.Y. Ng, Lung-Chi Yuan, Ignac J. Jakovac, J. Bryan Jones, Enzymes in organic synthesis-29 : Preparations of enantiomerically pure cis -2,3- and 2,4-dimethyl lactones via horse liver alcohol dehydrogenase-catalyzed oxidations☆☆☆ Tetrahedron. ,vol. 40, pp. 1235- 1243 ,(1984) , 10.1016/S0040-4020(01)82410-8