TP53 in Carcinogenesis and Cancer Prevention

摘要: Since its discovery in 1979, the tumor suppressor gene TP53 has been one of main focuses cancer research. This is altered at high frequency most types human cancers and studies on TP53-deficient mice have shown that lack p53 protein function predisposes to early (Donehower et al. 1992). In humans, inheritance a mutation molecular basis Li-Fraumeni syndrome (LFS), rare predisposing multiple (Malkin 1990; Srivastava 1990). Extensive experimental evidences support essential control genetic stability cells exposed genotoxic stress. These observations led identify as “the ultimate gene” (Oren 1992), or only thing stands between us death by cancer” (Lane