Inhaled gases as novel neuroprotective therapies in the postcardiac arrest period.
作者： Michael Fries , Aurora Magliocca
DOI: 10.1097/MCC.0000000000000820
关键词:
摘要: PURPOSE OF REVIEW The purpose of this review is to summarize recent advances about inhaled gases as novel neuroprotective agents in the postcardiac arrest period. RECENT FINDINGS Inhaled gases, nitric oxide (NO) and molecular hydrogen (H2), noble xenon (Xe) argon (Ar) have shown properties after resuscitation. In experimental settings, protective effect these has been demonstrated both in-vitro studies animal models cardiac arrest. They attenuate neuronal degeneration improve neurological function resuscitation acting on different pathophysiological pathways. Safety Xe H2 reported phase 1 clinical trials. A randomized 2 trial showed effects Xe, combined with targeted temperature management. inhalation for 24 h preserves white matter integrity measured by fractional anisotropy diffusion tensor MRI. SUMMARY Ar, NO, consistently studies. Ventilation appears be well tolerated pigs preliminary human Results from 3 trials are needed assess their efficacy treatment brain injury.
sci-hub.st 参考文章(45)
N. P. Franks, R. Dickinson, S. L. M. de Sousa, A. C. Hall, W. R. Lieb, How does xenon produce anaesthesia Nature. ,vol. 396, pp. 324- 324 ,(1998) , 10.1038/24525
Matthias Derwall, Andreas Ebeling, Kay Wilhelm Nolte, Joachim Weis, Rolf Rossaint, Fumito Ichinose, Christoph Nix, Michael Fries, Anne Brücken, Inhaled nitric oxide improves transpulmonary blood flow and clinical outcomes after prolonged cardiac arrest: a large animal study Critical Care. ,vol. 19, pp. 328- 328 ,(2015) , 10.1186/S13054-015-1050-2
Jerry P. Nolan, Jasmeet Soar, Alain Cariou, Tobias Cronberg, Véronique R. M. Moulaert, Charles D. Deakin, Bernd W. Bottiger, Hans Friberg, Kjetil Sunde, Claudio Sandroni, European Resuscitation Council and European Society of Intensive Care Medicine 2015 guidelines for post-resuscitation care. Intensive Care Medicine. ,vol. 41, pp. 2039- 2056 ,(2015) , 10.1007/S00134-015-4051-3
Mali Mathru, Ruksana Huda, Daneshvari R. Solanki, Stephen Hays, John D. Lang, Inhaled nitric oxide attenuates reperfusion inflammatory responses in humans. Anesthesiology. ,vol. 106, pp. 275- 282 ,(2007) , 10.1097/00000542-200702000-00015
Anne Brücken, Pinar Kurnaz, Christian Bleilevens, Matthias Derwall, Joachim Weis, Kay Nolte, Rolf Rossaint, Michael Fries, Delayed Argon Administration Provides Robust Protection Against Cardiac Arrest-Induced Neurological Damage Neurocritical Care. ,vol. 22, pp. 112- 120 ,(2015) , 10.1007/S12028-014-0029-1
Yu-Mi Ryang, Astrid V. Fahlenkamp, Rolf Rossaint, Dominik Wesp, Philip D. Loetscher, Cordian Beyer, Mark Coburn, Neuroprotective effects of argon in an in vivo model of transient middle cerebral artery occlusion in rats Critical Care Medicine. ,vol. 39, pp. 1448- 1453 ,(2011) , 10.1097/CCM.0B013E31821209BE
John D Lang, Xinjun Teng, Phillip Chumley, Jack H Crawford, T Scott Isbell, Balu K Chacko, Yuliang Liu, Nirag Jhala, D Ralph Crowe, Alvin B Smith, Richard C Cross, Luc Frenette, Eric E Kelley, Diana W Wilhite, Cheryl R Hall, Grier P Page, Michael B Fallon, J Steven Bynon, Devin E Eckhoff, Rakesh P Patel, None, Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation Journal of Clinical Investigation. ,vol. 117, pp. 2583- 2591 ,(2007) , 10.1172/JCI31892
Astrid V. Fahlenkamp, Rolf Rossaint, Hajo Haase, Hussam Al Kassam, Yu-Mi Ryang, Cordian Beyer, Mark Coburn, The noble gas argon modifies extracellular signal-regulated kinase 1/2 signaling in neurons and glial cells European Journal of Pharmacology. ,vol. 674, pp. 104- 111 ,(2012) , 10.1016/J.EJPHAR.2011.10.045
Sheng-Kwei Song, Jun Yoshino, Tuan Q. Le, Shiow-Jiuan Lin, Shu-Wei Sun, Anne H. Cross, Regina C. Armstrong, Demyelination increases radial diffusivity in corpus callosum of mouse brain. NeuroImage. ,vol. 26, pp. 132- 140 ,(2005) , 10.1016/J.NEUROIMAGE.2005.01.028
Giuseppe Ristagno, Francesca Fumagalli, Ilaria Russo, Simona Tantillo, Davide Danilo Zani, Valentina Locatelli, Marcella De Maglie, Deborah Novelli, Lidia Staszewsky, Tarcisio Vago, Angelo Belloli, Mauro Di Giancamillo, Michael Fries, Serge Masson, Eugenio Scanziani, Roberto Latini, Postresuscitation treatment with argon improves early neurological recovery in a porcine model of cardiac arrest. Shock. ,vol. 41, pp. 72- 78 ,(2014) , 10.1097/SHK.0000000000000049