Nerve cross-bridging to enhance nerve regeneration in a rat model of delayed nerve repair.

作者: Tessa Gordon , Michael Hendry , Christine A. Lafontaine , Holliday Cartar , Jennifer J. Zhang

DOI: 10.1371/JOURNAL.PONE.0127397

关键词:

摘要: There are currently no available options to promote nerve regeneration through chronically denervated distal stumps. Here we used a rat model of delayed repair asking prior insertion side-to-side cross-bridges between donor tibial (TIB) and recipient common peroneal (CP) stump ameliorates poor regeneration. First, numbers retrogradely-labelled TIB neurons that grew axons into the within three months, increased with size perineurial windows opened in CP nerves. Equal regenerated stumps either side cross-bridges, not being affected by target neurotrophic effects, or removing perineurium insert 5-9 cross-bridges. Second, were coapted months after inserting 0-9 number 1) their 2) motor nerves reinnervated extensor digitorum longus (EDL) muscle five was determined counting unit estimation (MUNE), respectively. We found but more promoted reinnervation EDL all motoneurons as compared only 33% regenerating when inserted. The same 3-fold increase sensory found. In conclusion, ameliorate possibly sustaining growth-permissive state Such autografts may be human surgery improve outcomes unavoidable delays.

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