Promise of Blood- and Bone Marrow-Derived Stem Cell Transplantation for Functional Cardiac Repair: Putting It in Perspective With Existing Therapy

摘要: Intracoronary transplantation of peripheral blood- or bone marrow-derived cells, as tested in several recent trials, is associated with moderate increases left ventricular (LV) ejection fraction (EF) and a small reduction LV end-systolic volumes. Substantial variability exists between most them are based on number patients. Meta-analyses estimated an increase EF 3% to 4% more comparison control In this review, the effects put into perspective established treatment options for acute myocardial infarction (AMI), such thrombolysis percutaneous interventions pharmacotherapy aimed at favorably influencing cardiac remodeling process. Changes functional morphometric parameters performance after cell therapy appear be range observed reperfusion therapy, pharmacotherapeutic renin-angiotensin-aldosterone pathway, beta-blockers AMI.