PIK3CA mutational status and overall survival in patients with cervical cancer treated with radical chemoradiotherapy.

摘要: Abstract Objective Mutational activation of PIK3CA is associated with poor prognosis in patients solid tumors, and may predict favorable response to PI3K/AKT/mTOR pathway inhibitors. However, mutational status has not previously been evaluated cervical carcinoma treated radical chemoradiotherapy (CRT). The aims this study were (1) evaluate the frequency mutations cancer CRT (2) examine effect tumor pre-treatment biopsies on overall survival (OS) progression-free (PFS). Methods Patients cancer, at a single institution CRT, from 1999 2008, eligible for retrospective study. Pre-treatment ( n =157) retrieved. Genomic DNA was extracted blocks, exons 9 20 gene sequenced mutations. Results Eighty-two tumors both exon 20. 19/82 (23%) mutation positive; these 84% squamous cell carcinomas. 79% 9. strongly FIGO stage IB/II patients, unadjusted HR 6.0 (95% CI 2.1–17.5), p =0.0002, but III/IVA 1.0 0.32–3.1), =0.98. Conclusions In cervix cancers. Further evaluation larger dataset will be required validate findings inform potential clinical trials designs involving