Vitamin D sufficiency in pregnancy

摘要: Better evidence is required to establish optimal levels and need for supplementation One year ago, the chief medical officers of United Kingdom recommended that “All pregnant breastfeeding women should take a daily supplement containing 10 μg (400 IU) vitamin D,” counter high prevalence D deficiency in women. This was aimed at reducing associated consequences deficiency, such as rickets children osteomalacia adults.1 In linked meta-analysis (doi:10.1136/bmj.f1169), Aghajafari colleagues look beyond bone health other adverse outcomes mother baby.2 Previous systematic reviews have highlighted challenges combining data from different studies, including diverse definitions variations assays used, use non-representative samples, varying study designs quality.3 4 A review published 2011 found insufficient quality studies conduct quantitative meta-analysis3; qualitative inconsistent. In subsequent review, rigorous assessment resulted meta-analyses only two observational five randomised controlled trials, with additional reviewed qualitatively.4 Combined …