Aß Toxicity in Alzheimer’s Disease

摘要: The first diagnosed Alzheimer’s disease patient was Auguste D (Fig. 1), a middle-aged woman cared for by Alsatian clinician-pathologist Alois Alzheimer from 1901 to 1906. died in her middle fifties, and Alzheimer, aided new histochemical methods, found brain tissue corrupted an abundance of extracellular intracellular lesions, the now-familiar plaques tangles (1). research provided direct evidence that dementia is consequence neurodegenerative mechanisms, not simple fact aging. A less diagnostic but equally apt description also came care D. As he tracked his patient’s progressively severe dementia, once asked write name. She task impossible replied, “I have lost myself” (2). We now know (AD) most common cause older individuals. number patients has grown case 1906 estimated 25 million worldwide (3). Complications resulting AD constitute fourth leading death United States, annual cost economy exceeds $140 billion (4,5). elderly population continues grow rapidly, represents imminent social as well medical problem.