Diagnostic value of cytokines and C-reactive protein in the first 24 hours of neonatal sepsis.

摘要: The first objective of this article was to determine the diagnostic accuracy tumor necrosis factor-alpha, interleukin-6 (IL-6), and interleukin-8 (IL-8) in differentiating infected from noninfected neonates during 24 hours suspected sepsis compare them currently used laboratory parameters: C-reactive protein (CRP), immature-to-total neutrophil ratio, leukocyte platelet count. secondary cytokine levels subpopulations neonates. Seventy-five premature 30 term infants were enrolled. Blood samples for "currently tests" obtained at suspicion ("0-hour") 18 later ("24-hours"). Patients classified as septic (48) or nonseptic (57). Thirty-two patients had positive blood cultures 16 showed clinical signs sepsis. Twenty early-onset 28 late-onset Sensitivity, specificity, negative predictive values (PPV NPV) calculated each test. Receiver-operating characteristic curves analyzed optimal thresholds. A combination CRP > 10 pg/mL plus IL-6 (sensitivity = 89%, specificity 73%, PPV 70%, NPV 90%) best "0-hour" test, 78%, 94%) "24-hours" Lower 0-hour (p 0.018) IL-8 0.023) detected among with coagulase-negative staphylococci then other bacteria. In conclusion, a + provided additional differentiation between