Lanthanum doped dicalcium phosphate bone cements for potential use as filler for bone defects
作者： Ali Motameni , Ammar Z. Alshemary , Ali Deniz Dalgic , Dilek Keskin , Zafer Evis
DOI: 10.1016/J.MTCOMM.2020.101774
关键词:
摘要: Abstract The bone defects arising as a result of trauma should be filled to provide framework support and encourage the growth new living tissues. Among many synthetic graft substitutes, self-hardening calcium phosphate (CP) cements have been widely used repair hard tissue defects. In this study, pure dicalcium (DCP) lanthanum (La) modified (La-DCP) were prepared based on acid/base reaction between β- tricalcium (βTCP) (or La- βTCP) monocalcium monohydrate (MCPM) in presence water. characterized using XRD, FTIR SEM techniques verify both La doping explore alterations structural molecular properties upon doping. With minimum addition La3+ ions (0.090 mol), phase brushite transformed into monetite plate-like crystals turned spheroid particles. setting times DCP cement declined gradually boosting amount lattice. As rose from 0 0.225 mol, compressive strength also increased 7.90 ± 0.8 9.64 ± 1.47 MPa. dissolution rate improved with ions. Adsorption/desorption Fetal bovine serum (FBS) on/from showed higher protein loading La-DCP than DCP. vitro experiments proliferation, adhesion, osteogenic differentiation Sarcoma (Saos-2) cells indicated that 0.225 mol promoted these compared Results suggested (0.225 mol) incorporated (2La-DCP) has potential filler material.
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