NADPH oxidases: Current aspects and tools.

作者: Katrin Schröder

DOI: 10.1016/J.REDOX.2020.101512

关键词:

摘要: Reactive oxygen species (ROS) have been shown or at least suggested to play an essential role for cellular signaling as second messengers. NADPH oxidases represent a source of controlled ROS formation. Accordingly, understanding the individual bears potential interfere with intracellular cascades without disturbing itself. Many tools developed study inhibit functions and roles oxidases. This short review summarizes diseases, potentially associated oxidases, genetically modified animals, inhibitors.

参考文章(67)
Tamara Seredenina, Gianpaolo Chiriano, Aleksandra Filippova, Zeynab Nayernia, Zahia Mahiout, Laetitia Fioraso-Cartier, Olivier Plastre, Leonardo Scapozza, Karl-Heinz Krause, Vincent Jaquet, A subset of N-substituted phenothiazines inhibits NADPH oxidases Free Radical Biology and Medicine. ,vol. 86, pp. 239- 249 ,(2015) , 10.1016/J.FREERADBIOMED.2015.05.023
Vincent Jaquet, Julien Marcoux, Eric Forest, Kevin G Leidal, Sally McCormick, Yvonne Westermaier, Remo Perozzo, Olivier Plastre, Laetitia Fioraso‐Cartier, Becky Diebold, Leonardo Scapozza, William M Nauseef, Franck Fieschi, Karl‐Heinz Krause, Karen Bedard, NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action British Journal of Pharmacology. ,vol. 164, pp. 507- 520 ,(2011) , 10.1111/J.1476-5381.2011.01439.X
S Wind, K Beuerlein, T Eucker, H Müller, P Scheurer, ME Armitage, H Ho, HHHW Schmidt, K Wingler, Comparative pharmacology of chemically distinct NADPH oxidase inhibitors. British Journal of Pharmacology. ,vol. 161, pp. 885- 898 ,(2010) , 10.1111/J.1476-5381.2010.00920.X
Sebastian Altenhöfer, Kim A. Radermacher, Pamela W.M. Kleikers, Kirstin Wingler, Harald H.H.W. Schmidt, Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement Antioxidants & Redox Signaling. ,vol. 23, pp. 406- 427 ,(2015) , 10.1089/ARS.2013.5814
Helmut Grasberger, Xavier De Deken, Olga Barca Mayo, Houssam Raad, Mia Weiss, Xiao-Hui Liao, Samuel Refetoff, Mice deficient in dual oxidase maturation factors are severely hypothyroid. Molecular Endocrinology. ,vol. 26, pp. 481- 492 ,(2012) , 10.1210/ME.2011-1320
Davide Gianni, Nicolas Taulet, Hui Zhang, Celine DerMardirossian, Jeremy Kister, Luis Martinez, William R. Roush, Steven J. Brown, Gary M. Bokoch, Hugh Rosen, A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells ACS Chemical Biology. ,vol. 5, pp. 981- 993 ,(2010) , 10.1021/CB100219N
Koji Tanaka, Yoshinori Fujimoto, Masako Suzuki, Yasuaki Suzuki, Takaaki Ohtake, Hiroyuki Saito, Yutaka Kohgo, PI3‐kinase p85α Is a Target Molecule of Proline‐rich Antimicrobial Peptide to Suppress Proliferation of ras‐Transformed Cells Japanese Journal of Cancer Research. ,vol. 92, pp. 959- 967 ,(2001) , 10.1111/J.1349-7006.2001.TB01187.X
Fabiana Tirone, Laura Radu, Constantin T. Craescu, Jos A. Cox, Identification of the binding site for the regulatory calcium-binding domain in the catalytic domain of NOX5. Biochemistry. ,vol. 49, pp. 761- 771 ,(2010) , 10.1021/BI901846Y
Ágnes Donkó, Éva Ruisanchez, Anna Orient, Balázs Enyedi, Réka Kapui, Zalán Péterfi, Xavier de Deken, Zoltán Benyó, Miklós Geiszt, Urothelial cells produce hydrogen peroxide through the activation of Duox1 Free Radical Biology and Medicine. ,vol. 49, pp. 2040- 2048 ,(2010) , 10.1016/J.FREERADBIOMED.2010.09.027
Yves Gorin, Rita C. Cavaglieri, Khaled Khazim, Doug-Yoon Lee, Francesca Bruno, Sachin Thakur, Paolo Fanti, Cédric Szyndralewiez, Jeffrey L. Barnes, Karen Block, Hanna E. Abboud, Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes American Journal of Physiology-renal Physiology. ,vol. 308, ,(2015) , 10.1152/AJPRENAL.00396.2014