Biological stimuli responsive drug carriers based on keratin for triggerable drug delivery
作者： Qinmei Li , Lijun Zhu , Ruigang Liu , Da Huang , Xin Jin
DOI: 10.1039/C2JM34136K
关键词:
摘要: A novel drug carrier with dual triggerable release properties based on keratin graft poly(ethylene glycol) (keratin-g-PEG) copolymers is reported. Keratin-g-PEG different densities are synthesized through thiol–ene click chemistry. Taking advantage of the amphiphilicity and thiol groups copolymer, nanoparticles stabilized PEG chains as core, bearing glutathione (GSH) cleavable cross-links, fabricated in aqueous solutions. The keratin-g-PEG copolymer can serve excellent carriers for doxorubicin hydrochloride salt (DOX·HCl) a highest loading capacity 18.1% (w/w). loaded DOX sensitive to concentration GSH, especially at GSH cellular level. Trypsin further trigger nanoparticles. In vitro uptake experiments indicate that released from DOX-loaded be internalized into cells efficiently, shows faster nuclei under higher concentrations. have promising applications intracellular delivery cancer therapy.
rsc.org
sci-hub.se 参考文章(57)
L. David Arscott, Donna M. Veine, Charles H. Williams, Mixed Disulfide with Glutathione as an Intermediate in the Reaction Catalyzed by Glutathione Reductase from Yeast and as a Major Form of the Enzyme in the Cell Biochemistry. ,vol. 39, pp. 4711- 4721 ,(2000) , 10.1021/BI9926431
V. Bütün, N. C. Billingham, S. P. Armes, SYNTHESIS OF SHELL CROSS-LINKED MICELLES WITH TUNABLE HYDROPHILIC/HYDROPHOBIC CORES Journal of the American Chemical Society. ,vol. 120, pp. 12135- 12136 ,(1998) , 10.1021/JA981932U
Tadanori Mayumi, Naoki Okada, Shinsaku Nakagawa, Jian-Qing Gao, Yusuke Eto, Yasuo Yoshioka, Fumiko Sekiguchi, Shinnosuke Kurachi, Tomohiro Morishige, Xinglei Yao, Hikaru Watanabe, Ratima Asavatanabodee, Fuminori Sakurai, Hiroyuki Mizuguchi, Yuka Okada, Yohei Mukai, Yasuo Tsutsumi, Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration Journal of Controlled Release. ,vol. 122, pp. 102- 110 ,(2007) , 10.1016/J.JCONREL.2007.06.010
Michihiro Iijima, Yukio Nagasaki, Takashi Okada, Masao Kato, Kazunori Kataoka, Core-Polymerized Reactive Micelles from Heterotelechelic Amphiphilic Block Copolymers Macromolecules. ,vol. 32, pp. 1140- 1146 ,(1999) , 10.1021/MA9815962
Todd Hoare, Jesus Santamaria, Gerardo F. Goya, Silvia Irusta, Debora Lin, Samantha Lau, Robert Padera, Robert Langer, Daniel S. Kohane, A Magnetically Triggered Composite Membrane for On-Demand Drug Delivery Nano Letters. ,vol. 9, pp. 3651- 3657 ,(2009) , 10.1021/NL9018935
Kanjiro Miyata, Yoshinori Kakizawa, Nobuhiro Nishiyama, Yuichi Yamasaki, Tsunamasa Watanabe, Michinori Kohara, Kazunori Kataoka, Freeze-dried formulations for in vivo gene delivery of PEGylated polyplex micelles with disulfide crosslinked cores to the liver. Journal of Controlled Release. ,vol. 109, pp. 15- 23 ,(2005) , 10.1016/J.JCONREL.2005.09.043
Jinqiang Jiang, Bo Qi, Martin Lepage, Yue Zhao, Polymer Micelles Stabilization on Demand through Reversible Photo-Cross-Linking Macromolecules. ,vol. 40, pp. 790- 792 ,(2007) , 10.1021/MA062493J
Sherwin Lehrer, Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. Biochemistry. ,vol. 10, pp. 3254- 3263 ,(1971) , 10.1021/BI00793A015
Jacob N. Israelachvili, D. John Mitchell, Barry W. Ninham, Theory of self-assembly of hydrocarbon amphiphiles into micelles and bilayers Journal of the Chemical Society, Faraday Transactions. ,vol. 72, pp. 1525- 1568 ,(1976) , 10.1039/F29767201525
Sun Hwa Kim, Ji Hoon Jeong, Soo Hyeon Lee, Sung Wan Kim, Tae Gwan Park, Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer. Journal of Controlled Release. ,vol. 129, pp. 107- 116 ,(2008) , 10.1016/J.JCONREL.2008.03.008