Methods and compositions for diagnosis, staging and prognosis of prostate cancer

摘要: The present invention provides, inter alia, novel methods and compositions for the diagnosis, staging prognosis of prostate cancer, based on DNA methylation and/or modulation gene expression, including transcriptional silencing. Preferred diagnostic prognostic nucleic acid protein markers include at least one of: differentially (relative to benign tissue) down-regulated sequences corresponding zinc finger 185 (ZNF 185), secretory (PSP94), bullous pemphigoid antigen (BPAG), supervillin (SVIL), proline rich membrane anchor 1 (PRIMA1), TU3A, FLJ14084, KIAA1210, Sorbin SH3 domain containing (SORBS1), C21orf63; up-regulated MARCKS-like (MLP) SRY (sex determining region Y)-box 4 (SOX4), fatty binding 5 (FABP5), MAL2, Erg-2.