Physiopathology of Hepatocellular Carcinoma
作者： J.C. Nault , J. Zucman-Rossi
DOI: 10.1016/B978-0-12-386456-7.04213-1
关键词:
摘要: Hepatocellular carcinoma (HCC) is a heterogeneous disease at both the genetic and phenotypic levels. Combination of (single-nucleotide polymorphism) clinical features models level risk to develop HCC on cirrhosis. Moreover, recent advances in next-generation sequencing have revealed new insights physiopathology HCC. Major pathways involved liver carcinogenesis are TERT promoter mutations telomere maintenance; Wnt/β-catenin pathway; TP53 cell cycle regulator; chromatin remodeling genes; NRF2 / KEAP1 , PI3K AKT MTOR RAS RAF MAP kinase pathways. Altogether, epigenetic alterations linked with tumor phenotype exposition specific factors. This knowledge will form backbone future personalized care.
sci-hub.se 参考文章(61)
Cyril Torre, Christine Perret, Sabine Colnot, Molecular determinants of liver zonation. Progress in Molecular Biology and Translational Science. ,vol. 97, pp. 127- 150 ,(2010) , 10.1016/B978-0-12-385233-5.00005-2
Sean P. Cleary, William R. Jeck, Xiaobei Zhao, Kui Chen, Sara R. Selitsky, Gleb L. Savich, Ting-Xu Tan, Michael C. Wu, Gad Getz, Michael S. Lawrence, Joel S. Parker, Jinyu Li, Scott Powers, Hyeja Kim, Sandra Fischer, Maha Guindi, Anand Ghanekar, Derek Y. Chiang, Identification of driver genes in hepatocellular carcinoma by exome sequencing Hepatology. ,vol. 58, pp. 1693- 1702 ,(2013) , 10.1002/HEP.26540
Nam Jin Yoo, Hyung Ran Kim, Yoo Ri Kim, Chang Hyeok An, Sug Hyung Lee, Somatic mutations of the KEAP1 gene in common solid cancers. Histopathology. ,vol. 60, pp. 943- 952 ,(2012) , 10.1111/J.1365-2559.2012.04178.X
John D. Hayes, Michael McMahon, NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer Trends in Biochemical Sciences. ,vol. 34, pp. 176- 188 ,(2009) , 10.1016/J.TIBS.2008.12.008
J Zucman-Rossi, S Benhamouche, C Godard, S Boyault, G Grimber, C Balabaud, A S Cunha, P Bioulac-Sage, C Perret, Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas. Oncogene. ,vol. 26, pp. 774- 780 ,(2007) , 10.1038/SJ.ONC.1209824
André Lechel, Henne Holstege, Yvonne Begus, Andrea Schienke, Kenji Kamino, Ulrich Lehmann, Stefan Kubicka, Peter Schirmacher, Jos Jonkers, K. Lenhard Rudolph, Telomerase Deletion Limits Progression of p53-Mutant Hepatocellular Carcinoma With Short Telomeres in Chronic Liver Disease Gastroenterology. ,vol. 132, pp. 1465- 1475 ,(2007) , 10.1053/J.GASTRO.2007.01.045
Mark Wade, Yao-Cheng Li, Geoffrey M Wahl, None, MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nature Reviews Cancer. ,vol. 13, pp. 83- 96 ,(2013) , 10.1038/NRC3430
Hui Shen, Peter W. Laird, Interplay Between the Cancer Genome and Epigenome Cell. ,vol. 153, pp. 38- 55 ,(2013) , 10.1016/J.CELL.2013.03.008
Vinod Kumar, Naoya Kato, Yuji Urabe, Atsushi Takahashi, Ryosuke Muroyama, Naoya Hosono, Motoyuki Otsuka, Ryosuke Tateishi, Masao Omata, Hidewaki Nakagawa, Kazuhiko Koike, Naoyuki Kamatani, Michiaki Kubo, Yusuke Nakamura, Koichi Matsuda, Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma Nature Genetics. ,vol. 43, pp. 455- 458 ,(2011) , 10.1038/NG.809
Jessica Zucman-Rossi, Emmanuelle Jeannot, Jeanne Tran Van Nhieu, Jean-Yves Scoazec, Catherine Guettier, Sandra Rebouissou, Yannick Bacq, Emmanuelle Leteurtre, Valérie Paradis, Sophie Michalak, Dominique Wendum, Laurence Chiche, Monique Fabre, Lucille Mellottee, Christophe Laurent, Christian Partensky, Denis Castaing, Elie Serge Zafrani, Pierre Laurent-Puig, Charles Balabaud, Paulette Bioulac-Sage, Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. Hepatology. ,vol. 43, pp. 515- 524 ,(2006) , 10.1002/HEP.21068