Evaluation of plasma cystatin C as a marker for glomerular filtration rate in patients with type 2 diabetes.

摘要: Aim: To evaluate plasma cystatin C as a marker of the glomerular filtration rate in patients with type 2 diabetes and their age sex-matched controls. Materials methods: Forty-seven one decade 51 non-diabetic control subjects were studied. Plasma was measured by particle-enhanced turbidimetric immunoassay new application for Hitachi 704 analyzer. For comparison, creatinine clearance measured. The 5 1 Cr-EDTA single injection method utilized reference. Results: In correlation coefficient between 0.774 (Spearman's coefficient) that 0.556 (p = 0.001 difference). 0.411. receiver operating characteristic (ROC) curve analysis diagnostic accuracy significantly better than 0.047) or 0.001). best efficiency (98%) obtained when cut-off limit set at 1.32 mg/l. group coefficients were: 0.627, 0.466 0.416. area under ROC plot also greatest group, but marginally either 0.05) 0.08). Among various non-renal causes may have interfered concentrations reducing correlations. Conclusions: Cystatin measurement is more sensitive specific test GFR its clearance, normal only slightly reduced. If an elevated concentration found, factors to be excluded. described here can easily applied most clinical chemistry analyzers therefore useful daily practice.