Prostate Cancer Genomics: Recent Advances and the Prevailing Underrepresentation from Racial and Ethnic Minorities.
作者： Shyh-Han Tan , Gyorgy Petrovics , Shiv Srivastava
DOI: 10.3390/IJMS19041255
关键词:
摘要: Prostate cancer (CaP) is the most commonly diagnosed non-cutaneous and second leading cause of male deaths in United States. Among African American (AA) men, CaP prevalent malignancy, with disproportionately higher incidence mortality rates. Even after discounting influence socioeconomic factors, effect molecular genetic factors on racial disparity evident. Earlier studies basis for have focused heritable mutations single-nucleotide polymorphisms (SNPs). Most susceptibility alleles identified based genome-wide association (GWAS) were common, low-penetrance variants. Germline CaP-associated that are highly penetrant, such as those found HOXB13 BRCA2, usually rare. More recently, genomic enabled by Next-Gen Sequencing (NGS) technologies identification somatic contribute to tumorigenesis. These confirmed high prevalence ERG gene fusions PTEN deletions among Caucasian Americans novel alterations SPOP FOXA1 genes early stages CaP. Individuals ancestry other minorities often underrepresented these large-scale studies, which performed primarily using tumors from men European ancestry. The insufficient number specimens AA minority populations, together heterogeneity etiology across challenge generalizability findings projects. Efforts close this gap sequencing larger numbers tumor more diverse although still at an stage, discovered distinct alterations. research can a direct impact diagnosis CaP, stratification patients treatment, help address This review examines progress understanding genetics genomics highlight need increase representation populations.
mdpi.com
core.ac.uk 
sci-hub.se 参考文章(230)
The use of racial, ethnic, and ancestral categories in human genetics research. American Journal of Human Genetics. ,vol. 77, pp. 519- 532 ,(2005) , 10.1086/491747
David P. Dearnaley, Dietrich Rothenbacher, Anne Tybjaerg-Hansen, Demetrius Albanes, Stephen Chanock, Henrik Gronberg, Johanna Schleutker, Tomonori Habuchi, Zsofia Kote-Jarai, Christopher A. Haiman, Federico Canzian, Thilo Dork, Dominika Wokolorczyk, Stephen N. Thibodeau, Peter Klarskov, Elio Riboli, Radka Kaneva, Freddie C. Hamdy, Lisa Cannon-Albright, James R. Marthick, Gianluca Severi, Rosalind A. Eeles, Robert A. Huddart, Sonja I. Berndt, Torben Falck Orntoft, Amanda Spurdle, Michael J. Thun, Elaine A. Ostrander, Antje E. Rinckleb, Fredrik Wiklund, Heiko Muller, Malgorzata Tymrakiewicz, Melissa C. Southey, Ali Amin Al Olama, W. Ryan Diver, Rudolf Kaaks, Danielle M. Karyadi, Angela Cox, Susan Gapstur, Aritaya Lophatonanon, Vanio Mitev, Guang-Wen Cao, Michael Borre, Kathleen A. Cooney, Daniel A. Leongamornlert, Tiina Wahlfors, Ahva Shahabi, Paul Pharoah, Maren Weischer, Stig E. Bojesen, Dallas R. English, Cezary Cybulski, Jarmo Virtamo, Norihiko Tsuchiya, M. Andreas Roder, James Farnham, Markus Aly, Borge G. Nordestgaard, Felicity Lose, Erika M. Kwon, Andreas Meyer, Chris Ogden, Judith A. Clements, Tim Key, Joanne Aitken, Mariana C. Stern, Alan Thompson, Emma J. Sawyer, Robert A. Stephenson, Michelle Guy, Jenny L. Donovan, Jong Y. Park, Yong-Jie Lu, Jan Lubinski, Karina Dalsgaard Sorensen, Amanda L. Hall, Nadiya Mahmud, Amit D. Joshi, Shintaro Narita, Briony Patterson, Suzanne Chambers, Hermann Brenner, Daniele Campa, Christiane Maier, Jyotsna Batra, Douglas F. Easton, Janet L. Stanford, Brian E. Henderson, Lynne T. O'Brien, Walther Vogel, David E. Neal, Shannon K. McDonnell, Joanne L. Dickinson, Roman Corral, Liesel FitzGerald, Rosemary A. Wilkinson, Jonathan Morrison, Sara Lindstrom, Hui-Yi Lin, Fredrick Schumacher, Nicholas Van As, Vincent S. Khoo, Gerald Andriole, John L. Hopper, Alan Horwich, Richard B. Hayes, Sara Benlloch, Meredith Yeager, Hong-Wei Zhang, Loic Le Marchand, Christopher C. Parker, Sue Ingles, Christopher J. Woodhouse, Peter Kraft, Graham G. Giles, Chavdar Slavov, Thomas A. Sellers, Colin S. Cooper, David J. Hunter, Ana Ray, Teuvo L. J. Tammela, Esther M. John, R. A. Frank Gardiner, Juergen Serth, Dan Schaid, Tim Christmas, Ruth Travis, Edward J. Saunders, Tokhir Dadaev, Ken Muir, Suzanne Kolb, Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study WOS. ,(2011)
Rong Na, Fang Liu, Penyin Zhang, Dingwei Ye, Chuanliang Xu, Qiang Shao, Jun Qi, Xiang Wang, Zhiwen Chen, Meilin Wang, Dalin He, Zhong Wang, Fangjian Zhou, Jianlin Yuan, Xin Gao, Qiang Wei, Jin Yang, Yang Jiao, Jun Ou‐Yang, Yao Zhu, Qijun Wu, Hongyan Chen, Daru Lu, Rong Shi, Xiaoling Lin, Haowen Jiang, Zhong Wang, Deke Jiang, Jielin Sun, S Lilly Zheng, Qing Ding, Zengnan Mo, Yinghao Sun, Jianfeng Xu, None, Evaluation of reported prostate cancer risk-associated SNPs from genome-wide association studies of various racial populations in Chinese men. The Prostate. ,vol. 73, pp. 1623- 1635 ,(2013) , 10.1002/PROS.22629
Sean V. Tavtigian, Jacques Simard, David H.F. Teng, Vicki Abtin, Michelle Baumgard, Audrey Beck, Nicola J. Camp, Arlene R. Carillo, Yang Chen, Priya Dayananth, Marc Desrochers, Martine Dumont, James M. Farnham, David Frank, Cheryl Frye, Siavash Ghaffari, Jamila S. Gupte, Rong Hu, Diana Iliev, Teresa Janecki, Edward N. Kort, Kirsten E. Laity, Amber Leavitt, Gilles Leblanc, Jodi McArthur-Morrison, Amy Pederson, Brandon Penn, Kelly T. Peterson, Julia E. Reid, Sam Richards, Marianne Schroeder, Richard Smith, Sarah C. Snyder, Brad Swedlund, Jeff Swensen, Alun Thomas, Martine Tranchant, Ann-Marie Woodland, Fernand Labrie, Mark H. Skolnick, Susan Neuhausen, Johanna Rommens, Lisa A. Cannon-Albright, A candidate prostate cancer susceptibility gene at chromosome 17p Nature Genetics. ,vol. 27, pp. 172- 180 ,(2001) , 10.1038/84808
Fredrik Wiklund, Björn-Anders Jonsson, Ingela Göransson, Anders Bergh, Henrik Grönberg, Linkage analysis of prostate cancer susceptibility: confirmation of linkage at 8p22–23 Human Genetics. ,vol. 112, pp. 414- 418 ,(2003) , 10.1007/S00439-003-0916-6
Dan Robinson, Eliezer M Van Allen, Yi-Mi Wu, Nikolaus Schultz, Robert J Lonigro, Juan-Miguel Mosquera, Bruce Montgomery, Mary-Ellen Taplin, Colin C Pritchard, Gerhardt Attard, Himisha Beltran, Wassim Abida, Robert K Bradley, Jake Vinson, Xuhong Cao, Pankaj Vats, Lakshmi P Kunju, Maha Hussain, Felix Y Feng, Scott A Tomlins, Kathleen A Cooney, David C Smith, Christine Brennan, Javed Siddiqui, Rohit Mehra, Yu Chen, Dana E Rathkopf, Michael J Morris, Stephen B Solomon, Jeremy C Durack, Victor E Reuter, Anuradha Gopalan, Jianjiong Gao, Massimo Loda, Rosina T Lis, Michaela Bowden, Stephen P Balk, Glenn Gaviola, Carrie Sougnez, Manaswi Gupta, Y Yu Evan, Elahe A Mostaghel, Heather H Cheng, Hyojeong Mulcahy, Lawrence D True, Stephen R Plymate, Heidi Dvinge, Roberta Ferraldeschi, Penny Flohr, Susana Miranda, Zafeiris Zafeiriou, Nina Tunariu, Joaquin Mateo, Raquel Perez-Lopez, Francesca Demichelis, Brian D Robinson, Marc Schiffman, David M Nanus, Scott T Tagawa, Alexandros Sigaras, Kenneth W Eng, Olivier Elemento, Andrea Sboner, Elisabeth I Heath, Howard I Scher, Kenneth J Pienta, Philip Kantoff, Johann S De Bono, Mark A Rubin, Peter S Nelson, Levi A Garraway, Charles L Sawyers, Arul M Chinnaiyan, None, Integrative clinical genomics of advanced prostate cancer Cell. ,vol. 161, pp. 1215- 1228 ,(2015) , 10.1016/J.CELL.2015.05.001
Mirjam Blattner, Daniel J. Lee, Catherine O'Reilly, Kyung Park, Theresa Y. MacDonald, Francesca Khani, Kevin R. Turner, Ya-Lin Chiu, Peter J. Wild, Igor Dolgalev, Adriana Heguy, Andrea Sboner, Sinan Ramazangolu, Haley Hieronymus, Charles Sawyers, Ashutosh K. Tewari, Holger Moch, Ghil Suk Yoon, Yong Chul Known, Ove Andrén, Katja Fall, Francecsa Demichelis, Juan Miguel Mosquera, Brian D. Robinson, Christopher E. Barbieri, Mark A. Rubin, SPOP mutations in prostate cancer across demographically diverse patient cohorts. Neoplasia. ,vol. 16, pp. 14- 20 ,(2014) , 10.1593/NEO.131704
Sofia Maia, Marta Cardoso, Pedro Pinto, Manuela Pinheiro, Catarina Santos, Ana Peixoto, Maria José Bento, Jorge Oliveira, Rui Henrique, Carmen Jerónimo, Manuel R. Teixeira, Identification of Two Novel HOXB13 Germline Mutations in Portuguese Prostate Cancer Patients PLOS ONE. ,vol. 10, pp. e0132728- ,(2015) , 10.1371/JOURNAL.PONE.0132728
Ying Han, Lisa B. Signorello, Sara S. Strom, Rick A. Kittles, Benjamin A. Rybicki, Janet L. Stanford, Phyllis J. Goodman, Sonja I. Berndt, John Carpten, Graham Casey, Lisa Chu, David V. Conti, Kristin A. Rand, W. Ryan Diver, Anselm J.M. Hennis, Esther M. John, Adam S. Kibel, Eric A. Klein, Suzanne Kolb, Loic Le Marchand, M. Cristina Leske, Adam B. Murphy, Christine Neslund-Dudas, Jong Y. Park, Curtis Pettaway, Timothy R. Rebbeck, Susan M. Gapstur, S. Lilly Zheng, Suh-Yuh Wu, John S. Witte, Jianfeng Xu, William Isaacs, Sue A. Ingles, Ann Hsing, Douglas F. Easton, Rosalind A. Eeles, Fredrick R. Schumacher, Stephen Chanock, Barbara Nemesure, William J. Blot, Daniel O. Stram, Brian E. Henderson, Christopher A. Haiman, , , Generalizability of established prostate cancer risk variants in men of African ancestry International Journal of Cancer. ,vol. 136, pp. 1210- 1217 ,(2015) , 10.1002/IJC.29066
Jin-Tang Dong, Chromosomal deletions and tumor suppressor genes in prostate cancer Cancer and Metastasis Reviews. ,vol. 20, pp. 173- 193 ,(2001) , 10.1023/A:1015575125780