Intravenous Infusion of Magnesium Chloride Improves Epicenter Blood Flow during the Acute Stage of Contusive Spinal Cord Injury in Rats

摘要: Abstract Vasospasm, hemorrhage, and loss of microvessels at the site contusive or compressive spinal cord injury lead to infarction initiate secondary degeneration. Here, we used intravenous injection endothelial-binding lectin followed by histology show that number perfused is decreased 80–90% as early 20 min following a moderate T9 contusion in adult female rats. Hemorrhage within also was maximal 20 min, consistent with its vasoconstrictive actions central nervous system (CNS). Microvascular blood flow recovered up 50% normal volume penumbra 6 h, but not epicenter. A comparison an endothelial cell marker suggested many fail be reperfused 48 h post-injury. The ischemia probably caused vasospasm vessels penetrating parenchyma, because repeated Doppler measurements over showed doubling total first 12 h. M...