Distribution of anti-Leu-7, anti-Leu-11a and anti-Leu-M1 immunoreactivity in the brain of the adult rat.
作者： Guido Reifenberger , J�rgenK. Mai , Stanislaw Krajewski , Wolfgang Wechsler
DOI: 10.1007/BF00218197
关键词:
摘要: This study reports a specific cross-reactivity of the three anti-human-hematopoietic-cell monoclonal antibodies, anti-Leu-7 (HNK-1), anti-Leu-11a (NKP-15), and anti-Leu-M1 (MMA), with different epitopes in brain adult rat. The distribution these rat is determined by means immunohistochemistry paraffin-embedded frontal serial sections. reaction pattern antibody very similar to that polyclonal antibodies against myelin basic protein. Both antisera give myelinated fibers. Immunoreaction products are found as diffuse, mostly punctiform material neuropil even more evident small granules coating cell surface many neurons. In white matter reveals moderate reactivity, which occurs predominantly spots fine-stranded within fiber tracts. Anti-Leu-M1 immunoreactivity present between bundles matter, where it has reticulate appearance, fine-granulated grey cortex nuclei. characteristic feature irregularly shaped immunopositive plaques, often located around blood vessels. cytoplasm glial neuronal cells appeared negative this MAB. exact topographical Leu-7 Leu-M1 throughout described. hypotheses concerning nature shared antigenicity hematopoietic nervous tissue discussed.
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