Cardiac functions of voltage-gated Ca(2+) channels: role of the pharmacoresistant type (E-/R-Type) in cardiac modulation and putative implication in sudden unexpected death in epilepsy (SUDEP).
作者： Etienne E. Tevoufouet , Erastus N. Nembo , Maxine Dibué-Adjei , Jürgen Hescheler , Filomain Nguemo
DOI: 10.1007/112_2014_21
关键词:
摘要: Voltage-gated Ca2+ channels (VGCCs) are ubiquitous in excitable cells. These play key roles many physiological events like cardiac regulation/pacemaker activity due to intracellular transients. In the myocardium, Cav1 subfamily (L-type: Cav1.2 and Cav1.3) is main contributor excitation–contraction coupling and/or pacemaking, whereas Cav3 (T-type: Cav3.1 Cav3.2) important rhythmically firing of nodal No established function has been attributed Cav2 family (E-/R-type: Cav2.3) despite accumulating evidence dysregulation observed upon deletion Cav2.3 gene, only member this so far detected cardiomyocytes. review, we summarize pathophysiological changes after ablation E-/R-type VGCC propose a mechanism action for channel. Also, considering role played by channel epilepsy its reported sensitivity antiepileptic drugs, putative involvement sudden unexpected death also discussed.
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