The Metabolomic Approach to the Diagnosis of Critical Illness

摘要: Advances in molecular and cell biology over the last two decades, including most notably sequencing of human genome, have undoubtedly determined a better understanding disease pathophysiology, more precise identification populations at risk for certain conditions. However, many questions remain unanswered using genomic approach alone, what gene products responses to insults are, given genetic abnormality. The study metabolome offers unique opportunity answer some these questions. represents combination all metabolites intermediate metabolism biological organism. metabolome, further down line from structure function, closely reflects activities functional level magnifies events that occur transcriptome proteome (Fig. 1).