A history of facial eczema (pithomycotoxicosis) research
作者： M. E. Di Menna , B. L. Smith , C. O. Miles
DOI: 10.1080/00288230909510519
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摘要: Abstract Facial eczema (pithomycotoxicosis), a photosensitisation of ruminants grazing pasture, has been known in New Zealand for over 100 years, but its cause, toxin produced by largely saprophytic fungus, Pithomyces chartarum, growing on litter at the base pasture and sporing profusely under warm moist conditions late summer autumn, was found only 50 years ago. As fungus spores it produces sporidesmin which, when eaten sheep, cattle, goats or deer, causes liver injury with inflammation blockage bile ducts. Phylloerythrin, photodynamic breakdown product chlorophyll, is no longer excreted circulates blood, causing lesions unpigmented skin affected animal exposed to sunlight. Lesions do not appear until least week after ingested, this lag period delayed discovery causative agent, first thought have an abnormal metabolite rapidly ryegrass. However, before role P. chartarum ...
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