Ginsenosides Rb1 and Rg1 effects on survival and neurite growth of MPP+-affected mesencephalic dopaminergic cells.

摘要: Ginsenosides Rb1 and Rg1 are the main active ingredients of Panax ginseng C.A. Meyer (Araliaceae). They appear to exert protection against ischaemia anoxic damage in animal models, suggesting an antioxidative cytoprotective role. In our study, primary cultures from embryonic mouse mesencephalon applied examine effects these two ginsenosides on neuritic growth dopaminergic cells their survival affected by 1-methyl-4-phenylpyridinium-iodide (MPP(+)). Ginsenoside (at 10 microM) enhanced neurons 19% compared untreated control. MPP(+) 1 significantly reduced number severely neuronal processes. Both counteracted degenerations protected lengths numbers neurites TH(+) cells. compounds however could not prevent cell loss caused MPP(+). Our study thus indicates partial neurotrophic neuroprotective actions culture.