Roles of TGF-beta in hepatic fibrosis

摘要: TGF-beta has multiple profibrogenic but also anti-inflammatory and immunosuppressive effects. The balance of these actions is required for maintaining tissue homeostasis an aberrant expression involved in a number disease processes the liver. In addition to its fibrogenic action leading transdifferentiation hepatic stellate cells into myofibroblasts, important negative regulator proliferation inducer apoptosis. major portion secreted as part inactive complex details activation process liver have not yet been elucidated. initially striking simplicity core TGF-beta/Smad signaling pathways rapidly giving way much more view intracellular signal transduction mechanisms recent work demonstrated importance cross-talk among different either specify, enhance, or inhibit responses. ubiquitous pathophysiologic relevance suggests measurement blood diagnostic tool. Other strategies aim at inhibition TGF-beta1 function synthesis primary target development antifibrotic advances cell biology opened several ways approach action.