Studies of the Metabolic Activity of Leukocytes from Patients with a Genetic Abnormality of Phagocytic Function*
作者： Beulah Holmes , Arthur R. Page , Robert A. Good
DOI: 10.1172/JCI105634
关键词:
摘要: Polymorphonuclear leukocytes from patients with chronic granulomatous disease respond to the phagocytosis of latex particles normal increments in glucose consumption, lactate production, Krebs' cycle activity, and lipid turnover. The these fail show respiration, direct oxidation glucose, hydrogen peroxide formation during particle uptake. It appears that stimulation respiration oxidative pathway metabolism are closely linked degranulation intracellular killing bacteria by polymorphonuclear leukocytes.
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