High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma

摘要: BACKGROUND Vascular endothelial growth factor (VEGF), a recently identified with significant angiogenic properties, is multifunctional cytokine that expressed in many tumors. High VEGF expression has been shown to correlate the incidence of metastasis and poor prognosis various cancers. In this study, authors investigated microvessel density (MVD) ductal pancreatic adenocarcinoma examined correlations among expression, clinicopathologic factors, clinical outcome. The especially focused on correlation between liver metastasis. METHODS Paraffin embedded tumor specimens 142 surgically resected pancreas carcinoma were immunohistochemically stained for MVD. MVD, outcome then statistically analyzed. RESULTS One hundred thirty-two (93%) adenocarcinomas positive protein by immunohistochemistry. A was observed positivity MVD (P < 0.0001). Multivariate logistic regression analysis indicated association high = 0.010) but no other such as age, size, histologic type, lymph node metastasis, venous invasion, neural peritoneal or local recurrence. Patients tumors showed moderate had significantly shorter survival than patients low none at all their 0.05). CONCLUSIONS These results indicate closely correlated seems be an important predictor both adenocarcinoma. Cancer 2000;88:2239–45. © 2000 American Society.