Expression and putative functions of melatonin receptors in malignant cells and tissues
作者： Cem Ekmekcioglu
DOI: 10.1007/S10354-014-0289-6
关键词:
摘要: Melatonin, the popular hormone of darkness, is primarily synthesized in pineal gland, and acts classically through G-protein coupled plasma membrane melatonin receptors MT1 MT2, respectively. Although some receptor mediated functions melatonin, especially those on (central) circadian system, have been more or less clarified, functional meaning MT-receptors various peripheral organs are still not sufficiently investigated yet. There is, however, accumulating evidence for oncostatic effects with both, antioxidative MT-receptor mechanisms possibly playing a role. This review briefly summarizes physiology MT-receptors, discusses expression function human cancer cells tissues.
springer.com
sci-hub.se 参考文章(111)
Michael Cohen, Marc Lippman, Bruce Chabner, PINEAL GLAND AND BREAST CANCER The Lancet. ,vol. 312, pp. 1381- 1382 ,(1978) , 10.1016/S0140-6736(78)92018-4
M. I. Masana, M. L. Dubocovich, Melatonin receptor signaling: finding the path through the dark. Science Signaling. ,vol. 2001, pp. 0- 0 ,(2001) , 10.1126/STKE.2001.107.PE39
Sylvia Aust, Theresia Thalhammer, Susanne Humpeler, Walter Jager, Martin Klimpfinger, Gerhard Tucek, Peter Obrist, Wolfgang Marktl, Edward Penner, Cem Ekmekcioglu, The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia. Journal of Pineal Research. ,vol. 36, pp. 43- 48 ,(2004) , 10.1046/J.1600-079X.2003.00095.X
Seithikurippu R. Pandi-Perumal, Ahmed S. BaHammam, Gregory M. Brown, D. Warren Spence, Vijay K. Bharti, Charanjit Kaur, Rüdiger Hardeland, Daniel P. Cardinali, Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes. Neurotoxicity Research. ,vol. 23, pp. 267- 300 ,(2013) , 10.1007/S12640-012-9337-4
Steven M. Reppert, David R. Weaver, Takashi Ebisawa, Cathy D. Mahle, Lee F. Kolakowski, Cloning of a melatonin-related receptor from human pituitary FEBS Letters. ,vol. 386, pp. 219- 224 ,(1996) , 10.1016/0014-5793(96)00437-1
Ismail Ben Soussia, Frédérique Mies, Robert Naeije, Vadim Shlyonsky, Melatonin down-regulates volume-sensitive chloride channels in fibroblasts. Pflügers Archiv: European Journal of Physiology. ,vol. 464, pp. 273- 285 ,(2012) , 10.1007/S00424-012-1139-2
Osamu Uchikawa, Kohji Fukatsu, Ryosuke Tokunoh, Mitsuru Kawada, Kiyoharu Matsumoto, Yumi Imai, Shuji Hinuma, Koki Kato, Hisao Nishikawa, Keisuke Hirai, Masaomi Miyamoto, Shigenori Ohkawa, Synthesis of a Novel Series of Tricyclic Indan Derivatives as Melatonin Receptor Agonists Journal of Medicinal Chemistry. ,vol. 45, pp. 4222- 4239 ,(2002) , 10.1021/JM0201159
Monica I. Masana, Suzanne Doolen, Cagatay Ersahin, Walid M. Al-Ghoul, Sue Piper Duckles, Margarita L. Dubocovich, Diana N. Krause, MT2Melatonin Receptors Are Present and Functional in Rat Caudal Artery Journal of Pharmacology and Experimental Therapeutics. ,vol. 302, pp. 1295- 1302 ,(2002) , 10.1124/JPET.302.3.1295
Hitoshi Okamura, Masao Doi, Jean-Michel Fustin, Yoshiaki Yamaguchi, Masahiro Matsuo, Mammalian circadian clock system: Molecular mechanisms for pharmaceutical and medical sciences☆ Advanced Drug Delivery Reviews. ,vol. 62, pp. 876- 884 ,(2010) , 10.1016/J.ADDR.2010.06.004
Charlotte von Gall, Jörg H. Stehle, David R. Weaver, Mammalian melatonin receptors: molecular biology and signal transduction. Cell and Tissue Research. ,vol. 309, pp. 151- 162 ,(2002) , 10.1007/S00441-002-0581-4