Longitudinal changes in echocardiographic measures of ventricular function after Fontan operation.

摘要: Background While numerous indices have been developed in an attempt to quantify ventricular function patients with single ventricle heart disease after Fontan, there are little data on how these parameters change over time. Methods A retrospective observational study was performed of individuals who underwent Fontan operation at Children's Hospital Philadelphia (CHOP) 2006 and 2007. Measurements fractional area (FAC), tricuspid annular planar systolic excursion (TAPSE), myocardial performance index (MPI), diastolic (s/d) ratio, strain rate were made offline. composite outcome protein-losing enteropathy (PLE), plastic bronchitis, transplant, or death created, compared between those did not meet the outcome. Results There 312 echocardiograms from 40 unique (75% male, 55% dominant right ventricle). The aggregate mean values for most assessed worse than what would be expected a healthy age-matched population. global longitudinal increased (worsened) by 0.014 (1/s) per year (P = .02), circumferential 0.011 .01). no difference 6 met endpoint vs not. Conclusion This demonstrates that decrease 10 years following operation. These measures may early signs cardiac dysfunction predate more obvious echocardiographic deterioration.