Drug discovery in the age of systems biology: the rise of computational approaches for data integration
作者： Murat Iskar , Georg Zeller , Xing-Ming Zhao , Vera van Noort , Peer Bork
DOI: 10.1016/J.COPBIO.2011.11.010
关键词:
摘要: The increased availability of large-scale open-access resources on bioactivities small molecules has a significant impact pharmacology facilitated mainly by computational approaches that digest the vast amounts data. We discuss here how data integration enables systemic views drug's action and allows to tackle complex problems such as prediction drug targets, repurposing, molecular mechanisms, cellular responses or side effects. particularly focus methods leverage various cell-based transcriptional, proteomic phenotypic profiles response in order gain view at molecular, whole-organism scale.
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