Protection from lethal audiogenic seizures in mice by physical restraint of movement.

摘要: Abstract To study the effects of physical restraint on audiogenic seizures, susceptible mice were restrained in various ways and compared with unrestrained controls for lethal seizures. Binding front limbs together and/or back together, suspending subjects harnesses, or restraining “body casts” not effective inhibiting but binding “hogtied” fashion was quite reducing incidence Various hypotheses evaluated light present results. The most plausible hypothesis related protection from seizures to disruption central neural activity normally evoked by bodily movements during