Comparative brain exposure to (-)-carbovir after (-)-carbovir or (-)-6-aminocarbovir intravenous infusion in rats.
作者： Yan‐Dong Wen , Rory P. Remmel , Phuong T. Pham , Robert Vince , Cheryl L. Zimmerman
关键词:
摘要: Purpose. Evaluate the ability of (-)-6-aminocarbovir ((-)-6AC) to improve CNS exposure (-)-carbovir ((-)-CBV).
springer.com
elsevier.com
sci-hub.se 参考文章(21)
R E Galinsky, B L Hoesterey, B D Anderson, D C Baker, Uptake kinetics of 2',3'-dideoxyinosine into brain and cerebrospinal fluid of rats: intravenous infusion studies. Journal of Pharmacology and Experimental Therapeutics. ,vol. 253, pp. 113- 118 ,(1990)
Shu‐hui Huang, Rory P. Remmel, Cheryl L. Zimmerman, The bioavailability and nonlinear clearance of (-)-carbovir in the rat. Pharmaceutical Research. ,vol. 8, pp. 739- 743 ,(1991) , 10.1023/A:1015850017201
R H Lupia, N Ferencz, J J Lertora, S K Aggarwal, W J George, K C Agrawal, Comparative pharmacokinetics of two prodrugs of zidovudine in rabbits: enhanced levels of zidovudine in brain tissue. Antimicrobial Agents and Chemotherapy. ,vol. 37, pp. 818- 824 ,(1993) , 10.1128/AAC.37.4.818
Rory P. Remmel, Yoon-Hee Yeom, Mei Hua, Robert Vince, Cheryl L. Zimmerman, Liquid chromatographic assay of carbovir, a carbocyclic nucleoside active against human immunodeficiency virus. Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 489, pp. 323- 331 ,(1989) , 10.1016/S0378-4347(00)82910-2
Robert Vince, Mei Hua, Synthesis and anti-HIV activity of carbocyclic 2',3'-didehydro-2',3'-dideoxy 2,6-disubstituted purine nucleosides. Journal of Medicinal Chemistry. ,vol. 33, pp. 17- 21 ,(1990) , 10.1021/JM00163A004
Robert Vince, Jay Brownell, Resolution of racemic carbovir and selective inhibition of human immunodeficiency virus by the (−) enantiomer Biochemical and Biophysical Research Communications. ,vol. 168, pp. 912- 916 ,(1990) , 10.1016/0006-291X(90)91115-9
B.D. Anderson, R.E. Galinsky, D.C. Baker, S.-C. Chi, B.L. Hoesterey, M.E. Morgan, K. Murakami, H. Mitsuya, Approaches toward the optimization of CNS uptake of anti-AIDS agents Journal of Controlled Release. ,vol. 19, pp. 219- 229 ,(1992) , 10.1016/0168-3659(92)90078-6
J.M. Gallo, L.N. Clark, J.T. Rubino, Pump delivery of azidothymidine: Potential for constant concentrations and improved brain delivery Journal of Controlled Release. ,vol. 9, pp. 249- 253 ,(1989) , 10.1016/0168-3659(89)90093-X
M E Morgan, S C Chi, K Murakami, H Mitsuya, B D Anderson, Central nervous system targeting of 2',3'-dideoxyinosine via adenosine deaminase-activated 6-halo-dideoxypurine prodrugs. Antimicrobial Agents and Chemotherapy. ,vol. 36, pp. 2156- 2165 ,(1992) , 10.1128/AAC.36.10.2156
Abdelkader Namane, Catherine Gouyette, Marie Paule Fillion, Gilles Fillion, Huynh Dinh Tam, Improved brain delivery of AZT using a glycosyl phosphotriester prodrug. Journal of Medicinal Chemistry. ,vol. 35, pp. 3039- 3044 ,(1992) , 10.1021/JM00094A018