Nimesulide analogues: From anti-inflammatory to antitumor agents.
作者： Mafalda Catarro , João L. Serrano , Susana S. Ramos , Samuel Silvestre , Paulo Almeida
DOI: 10.1016/J.BIOORG.2019.102966
关键词:
摘要: Abstract Nimesulide is a nonsteroidal anti-inflammatory drug possessing analgesic and antipyretic properties. This considered selective cyclooxygenase-2 (COX-2) inhibitor and, more recently, has been associated to antitumor activity. Thus, numerous works have developed modify the nimesulide skeleton aiming develop new potent COX-2 inhibitors as well potential anticancer agents. review intends provide an overview on analogues of nimesulide, including general synthetic approaches used for their preparation structural diversification main and/or
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