Docosahexaenoic acid supplementation during pregnancy as phospholipids did not improve the incorporation of this fatty acid into rat fetal brain compared with the triglyceride form

摘要: Abstract Prenatal docosahexaenoic acid (DHA) supply is important to ensure an adequate infant neurodevelopment. Several fat supplements with DHA under different chemical structures are available. There increased placental phospholipase activity at the end of pregnancy. The hypothesis this study was discern whether consumption during pregnancy as phospholipids (PLs) could be more available for uptake and fetal accretion than triglycerides (TGs) form. We aimed evaluate maternofetal status in pregnant rats fed PL from egg yolk or TG algae oil determine which source might most effective Three experimental diets were tested: 2.5% DHA-TG (n = 10), DHA-PL 9), 9% 9). total content these 2%, 12%, 38%, respectively. determined dietary absorption quantified fatty acids by gas chromatography maternal tissues. Dietary enhanced significantly absorption. However, animals highest PL-content diet (38% DHA-PL) stored absorbed liver, promoting hepatic steatosis, not observed lower (12% 2%). Despite higher PL-containing diets, tissues (including brain) did show major differences between DHA-TG–fed groups. conclude that form consumed rat gestation (PL TG) does differentially affect into brain, both lipid sources can equally used supplementation