International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 2: T2 substaging and prostate cancer volume.

摘要: The 2009 International Society of Urological Pathology consensus conference in Boston made recommendations regarding the standardization pathology reporting radical prostatectomy specimens. Issues relating to substaging pT2 prostate cancers according TNM 2002/2010 system, tumor size/volume and zonal location were coordinated by working group 2. A survey circulated before demonstrated that 74% 157 participants considered cancer be clinical and/or academic relevance. also revealed a considerable variation frequency pT2b substage cancer, which was likely consequence variable methodologies used distinguish pT2a from tumors. Overview literature indicates current criteria lack relevance majority (65.5%) attendees wished discontinue substaging. Therefore, substages should, at present, optional. Several studies have shown volume is significantly correlated with other clinicopathological features, including Gleason score extraprostatic extension tumor; however, most fail demonstrate this prognostic significance on multivariate analysis. Consensus reached regard some quantitative measure specimen, without prescribing specific methodology. Incorporation anterior dominant/index report accepted participants, but formal definition identifying features remained undecided.