Immunomodulatory and Anti-Inflammatory Strategies to Reduce Comorbidity Risk in People with HIV

作者: Aaren Kettelhut , Emily Bowman , Nicholas T. Funderburg

DOI: 10.1007/S11904-020-00509-Y

关键词:

摘要: In this review, we will discuss treatment interventions targeting drivers of immune activation and chronic inflammation in PWH. Potential strategies to prevent the progression comorbidities PWH have been identified. These studies include, among others, use statins modulate lipid alterations subsequent innate receptor activation, probiotics restore healthy gut microbiota reduce microbial translocation, hydroxychloroquine by altering Toll-like receptors function expression, canakinumab block action a major pro-inflammatory cytokine IL-1β. Although many discussed here show promise, due complex nature PWH, larger clinical are needed understand target prominent inflammatory cascades underlying these end-organ diseases.

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