Current status and future prospects of therapeutic drug monitoring and applied clinical pharmacology in antiretroviral therapy.

摘要: The consensus of current international guidelines for the treatment HIV infection is that data on therapeutic drug monitoring (TDM) non-nucleoside reverse transcriptase inhibitors and protease provide a framework implementation TDM in certain defined scenarios clinical practice. However, utility considered to be an individual basis until more are obtained from large trials showing benefit TDM. In April 2004, panel experts met Rome, Italy. This followed inaugural meeting Perugia, Italy, October 2000, which resulted article published AIDS 2002, 16(Suppl 1):S5-S37. objectives this second were review questions surrounding antiretroviral drugs discuss utility, concerns future prospects concentration care HIV-1-infected individuals. report, has been updated include material or presented at conferences up end September reviews pharmacokinetic pharmacodynamic reports issues discussed by panel, offering advice providers who may currently, considering incorporating into routine their patients. addition, formulated series position statements relevant interpretation can aid design trials.